Passage of Fibrinogen through the Blood Brain Barrier is Key Element in Neuroinflammatory Disease such as Multiple Sclerosis

A Neurology Today article summarizes the findings of work performed at the University of California, San Francisco, revealing how the fibrinogen activates neuroinflammation in a mouse model for multiple sclerosis.

Follow this link for the story: http://journals.lww.com/neurotodayonline/Fulltext/2013/01170/Imaging_Tracks_Fibrinogen_Activity_in_MS_Brain.2.aspx

This is the first study to show how leakage of fibrinogen through the blood brain barrier activates microglia and induces rapid clustering of microglia in the matrix around blood vessels, which contributes to axon damage and neuroinflammation.